Thursday, December 26, 2019

Contradictions in the Great Gatsby Essay - 1623 Words

Contradictions in the Great Gatsby They were known as the roaring twenty’s because the economy at the time was through the roof and people were partying all over the place. At the time there was a prohibition on the manufacturing and sales of intoxicating drinks. Since a lot of people did not feel like drinking gin they made in their bathtubs all the time, there was a huge market for organized crime. Organized criminals catered to the needs of the drinking public by illegally supplying them with liquor and made a fortune doing it. Even with all the crime in the jazz age, it will still be remembered for its glittering lights and unbridled romance. This just goes to show that life is filled with contradictions. Even with all the†¦show more content†¦Gatsby tries to chase the American Dream, yet his idea is tarnished. He throws parties to try and fit in with the socialites and his idea of the American Dream is doomed because he tries to buy his way into a society that will never accept him. On the other hand, the East Egg is snobbishly superior towards everyone else. This place also feels like heaven; immortal. Tom and Daisy Buchanan are a part of the East Egg society. East Eggers have inherited their wealth and dwell on the traditions of high class society. They did not work for their money so they do not appreciate it the way West Eggers do. Like the West Eggers, East Eggers have not obtained the American Dream either. Tom is rich and has a beautiful wife and on the outside it looks like he has the perfect life. The only problem is that he cheats on his wife with a woman that lives between East Egg and West Egg, Myrtle Wilson. Myrtles husband loves her, but she is a money chaser. She says, I thought he was a gentleman . . . but he wasnt fit to lick my shoe . . . he borrowed somebodys best suit to get married in . . . (Fitzgerald 39) She couldnt appreciate the fact that her husband was working hard to provide for her. She just wanted money and found it in a relationship with a married man. Here Fitzgerald shows the other side of the American Dream. Myrtle has the love but not the money, andShow MoreRelated Examine the contradictions in The Great Gatsby, including its narrative2958 Words   |  12 PagesExamine the contradictions in The Great Gatsby, including its narrative styles. The novel moves on two levels: Fitzgerald makes you see the magic and romance of Gatsbys vision of ideal love, dazzling the eye with wealth; yet, at the same time, the narrator pulls us down to earth revealing the immorality, waste and corruption of those who surround Gatsby and cause his death. Examine the contradictions in The Great Gatsby, including its narrative styles. One of Fitzgeralds main aimsRead MoreThe Great Gatsby By F. Scott Fitzgerald1512 Words   |  7 PagesThe Great Gatsby was written by the famous American writer F. Scott Fitzgerald that describes the fictional story of a cast of characters living in a town of West Egg in the summer of 1922. His books have been considered by as many a symbol for the ‘Jazz Age,’ a time of extraordinary wealth and promise, but Fitzgerald’s novels are much more than that, presenting the truth behind the twenties and creating an atmosphere, which has earned a permanent place in American literature. After the second industrialRead MoreContradictory Characters in the River Between and the Great Gatsby1559 Words   |  7 Pagesthoughts etc. of the particular character that oppose each other. Contradiction in a character arises, mainly, as a result of internal conflict within the character. It could also arise from other influences such as external conflicts or a moment of shock etc. or it could be the nature of the character to be contradictory to his or her actions, thoughts and speech. For the essay question, we will be looking at mainly two books: The Great Gatsby by F. Scott Fitzgerald and The River Between by NgÃ… «gÄ « wa Thiong’oRead MoreThe Great Gatsby Analysis1022 Words   |  5 PagesScott Fitzgerald’s The Great Gatsby explores the society of the 1920s and the fundamental clash between the East and West as a new money businessman lives a lavish lifestyle to win his past love. Although people with old money such as the Buchanans survive, Jay Gatsby dies. Gatsby, despite his dubious legality, literally and figuratively creates a self-made identity that collapses on the cusp of achieving his dream. In the scene beginning on page 110 where Nick imagines Gatsby falling in love withRead MoreThe Great Gatsby Analysis741 Words   |  3 Pageschasing the unreachable (Fitzgerald 180). In his 1925 novel The Great Gatsby, author F. Scott Fitzgerald suggests that making any progress whatsoever toward this aspiration often requires people to establish facades that enable them to progress socially, but that a crippled facade will backfire and cause detriment to its creator. In the passage where Nick realizes who Gatsby is on page 48, Nick observes two different versions of Gatsby—one that is reassuring and truthful and another who â€Å"pick[s] hisRead More Adultery in Great Gatsby Scarlet Letter Essay688 Words   |  3 Pages   Ã‚  Ã‚  Ã‚  Ã‚  The Scarlet Letter by Nathaniel Hawthorne and The Great Gatsby by F. Scott Fitzgerald are two novels, which address similar themes with completely opposite resolves. The authors use their main characters, Hester, Dimmesdale, Gatsby, and Daisy, in their respective works to present these themes. The action in both novels revolves around unfaithfulness, its effects on the characters, and the results of committing adultery, which prove to be antipode from one novel to the other. These antithesesRead MoreGreat Gatsby Scarlet Letter Essay690 Words   |  3 PagesJason Bello AP English March 22, 2000 The Scarlet Letter by Nathaniel Hawthorne and The Great Gatsby by F. Scott Fitzgerald are two novels, which address similar themes with completely opposite resolves. The authors use their main characters, Hester, Dimmesdale, Gatsby, and Daisy, in their respective works to present these themes. The action in both novels revolves around unfaithfulness, its effects on the characters, and the results of committing adultery, which prove to be antipode fromRead MoreThe Great Gatsby By F. Scott Fitzgerald1127 Words   |  5 Pagestrue in the text you have studies and how has the author sought to influence their readers.† Introduction The extent to which ones opinions and views can be altered without them even noticing is impeccable. F. Scott Fitzgerald, the author of ‘The Great Gatsby’, explores the ways in which one can influence a person’s thoughts in such a minute way that they themselves don’t even realise it. He, as a writer, is â€Å"communicative in a reserved way†. This leaves the readers perspective altered to believe whatRead MoreThe Great Gatsby By F. Scott Fitzgerald1036 Words   |  5 Pagesis seen as nothing but bloodshed. However, for many this allows them to shine in a way that they could not back at home. In The Great Gatsby, by F. Scott Fitzgerald, it is placed in the post war era. Gatsby, one of the main protagonists, is a war hero that fought in World War I. World War I is important to The Great Gatsby due to how integrated it is to the past of Gatsby and F. Scott Fitzgerald. In the beginning, Fitzgerald had many people in his life that played an influential part in his literaryRead MoreEssay On Owl Eyes In The Great Gatsby1085 Words   |  5 PagesThe Great Gatsby written in 1925 was a novel that expresses F. Scott Fitzgerald’s concerns for the direction that America was headed in during that decade. During the novel he repeatedly gives examples of the contrast of the economic classes; the thriving upper class in extravagant living conditions while the lower class lives in filth like â€Å"fields of ashes.† To criticize the American upper class during the nineteen twenties, F. Scott Fitzgerald uses vivid imagery in his revelation of Gatsby’s facade

Tuesday, December 17, 2019

Cyber Security Policies in the Private and Public Sector

Cyber Security Policies in the Private and Public Sector Cyber Security Vulnerabilities and Associated Threats of Cloud-Computing 16-03-2013 Table of contents Introduction†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦3-4 Cyber Security Vulnerabilities†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦4-5 Cyber Security Vulnerabilities, Threats and Actions.†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.....5 Session Hijacking†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.5-6 Virtual Machine Access†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦6 Service Availability†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦......6-7 Cryptography Flaws†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.7-8 Data Privacy†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦.8-9 Dependency on Internet†¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦Ã¢â‚¬ ¦..9-10 Denial of Service (DOS)†¦show more content†¦When an organization has decided to move on the cloud, then it should also consider the associated vulnerabilities and the threats. Some of the major vulnerabilities are discussed below: Session Hijacking It means that the cloud or the required service is hacked by the hackers using a valid session key. This key is used to gain the unauthorized access on the critical resources of the organization. Once hacked, the hackers can have the complete access on the systems, and they can perform any malicious activity they want to do, to hit the company resources. If proper and effective security measures are not followed in the infrastructure then it may cause a heavy business loss in terms of financial terms as well as the reputation of the organization. Probability of Occurrence The probability of occurrence of these types of attack is generally high. The reason being is that the attackers keep on continuously scan the system to find out the vulnerabilities in it. Once they gain the access, they just execute their jobs. Effective Policies amp; Procedures To mitigate this kind of risk, firewalls should be implemented in the system at the right places. Firewalls prevent unauthorized access of data. Rules and policies should be configured to protect the session keys. To increase the awareness among employees, a proper training should be given to them. For example, session monitoring shouldShow MoreRelatedCyber Security Role For Homeland Security Intelligence1153 Words   |  5 Pagesshown major flaws within the intelligence community. Those events led the creation of the Department of Homeland Security and with it pooled federal agencies into in umbrella for it to be centralized in order to be effective. There are three categories in which the Homeland Security Intelligence face in the 21st century. Those categories are technological, political, and cyber security. In this day in age everything from critical infrastructure, government information to money is being digitalizedRead MoreCyber Security : The Security Of The Nation s Computer And Telecommunications Infrastructure1091 Words   |  5 PagesCyber Security can be defined as â€Å"The security of the nation’s computer and telecommunications infrastructure that include military, all forms of communications networking, electrical grids and power plants.† (Dhillon, 2013) The attacks can involve both public and private sectors including: †¢ Government Agencies †¢ Banks †¢ Power Companies †¢ Any other companies that utilizes computer and telecommunication systems. Very little research exists regarding power in information system (IS) security. HoweverRead MoreThe European Union1015 Words   |  5 Pagesit placed on its public borrowing and financing of infrastructure. To meet its social responsibility the United Kingdom government started the private finance initiative. 1992 - Private finance initiative is the resultant means of financing infrastructure following the Maastricht agreement to reduce public sector borrowing requirement. It was first introduced in the 1992 Autumn Statement by Conservative Chancellor Norman Lamont. PFI was a means through which the private sector finances major infrastructureRead MoreDefence Policy And Military Strategy1134 Words   |  5 Pagesconcept of Defence has gradually changed as cyber security is streamlined into defence policy coupled with economic influence and globalisation. ‘In the military, information and intelligence operations, routine administrative functions, and a wide array of everyday jobs have been increasingly developed and transformed with the support of interconnected electro-electronic devices’ . Defence policy and military strategy go hand in hand and Defence policy have been directly linked to current economicRead MoreThe Emergency Management Response Team1581 Words   |  7 Pageselectric is a regulated distribution and transmission business of the private sector and owned by a limited number of investors. Oncors’ responsibility is to deliver reliable and safe electricity to the private sectors, so they can have the power to maintain productivity by keeping the backbone of our economy (oncor 2012). We are known as the â€Å"poles and wires† infrastructure company, we manage our business like the private sector does and our company invests in the latest technology and by puttingRead MoreObama Administrations Policy Views on Cybersecurity1338 Words   |  6 PagesTitle Page Contents Introduction Obama Administration’s Policy Views on Cybersecurity 1.1. Enhancing Resilience 1.2. Reducing Threats Obama and Bush Administrations 1.3. Bush Administration 1.4. Policy Similarities 1.5. Policy Differences Recommendations for Improvements 1.6 Cyber Czar Position 1.7 International Organization and joint punishment Works Cited Introduction The following document will provide information pertaining to presidential administrationsRead More Cyber Security Policies and Defense Contractors Essay1087 Words   |  5 PagesAbstract Cyber security policies in the private sector have been a challenging issue for major defense contractors, especially after recent attacks. As a result, the U.S. increased its strict enforcement against these companies by justifying its intervention to improve cyber security. The government would like to impose standards for companies who lack the proper protocol. Due to the revised and new procedures, corporations are responding by rejecting any congressional intervention. This has causedRead MoreA Supervisory Control And Data Acquisition1491 Words   |  6 Pagesand username sharing (Adams, 2015). Stuxnet was a worm that was created in June 2010 that was supposed to precisely target Siemens SCADA industrial software and equipment operating at Iranian nuclear facilities (Chung, 2013). Stuxnet was a cyber weapon that could alter and damage industrial control systems. These are the same systems that control water treatment plants, the electrical grid, and nuclear facilities all over the world (Ferran, 2012). â€Å"Although the worm was intended for a specificRead MoreThe Government s Methods Of Intervention891 Words   |  4 PagesThe government’s methods of intervention are to enhanced public/private collaboration, proposing new cybersecurity legislations, established partnerships to secure technology, data information sharing, protected consumers, and increase security on Federal networks† (Fact Sheet). By detecting common cyber dangers and obtain additional resources from the private sector assets can reduce the risk of threats against our country. Presi dent Obama and his Administration has addressed the major risk of cybersecurityRead MoreImportance of Cyber Security1744 Words   |  7 Pagesbecome prey to cyber threats. The United States Executive Office of the President stated, â€Å"The President identified cybersecurity as one of the top priorities of his administration in doing so, directed a 60-day review to assess polices.† (United States Executive Office of the President, 2009, p.2). Furthermore, critical infrastructure, our network, and internet alike are identified as national assets upon which the administration will orchestrate integrated cybersecurity policies without infringing

Monday, December 9, 2019

Financial Position and Operations System †MyAssignmenthelp.com

Question: Discuss about the Financial Position and Operations System. Answer: Introduction: The memo aims to discuss some of the important aspects from the financial statements of Capilano and addressing of the same to the board of directors clearly stating about some of the technical issues in the consolidation process. The memorandum to the board of directors has included the specific intricacies of the consolidation to the board and the possible avoidance of the general terms management. It has to be further noted the important aspects of the report has been stated from the annual report of the company. The main operation of Capilano Honey has been seen in terms of sourcing of network of over 600 loyal beeking families across Australian. The supplies of the company have been seen with 30 years. The operations of the company include the preservatives from the refined range of products. The composition of the different range of the products includes Capilano Classic Honey, Capilano Beeotic, Capilano Manuka Honey, Capilano Premium Selections and Capilano Creamed and pot set. In the recent itmes the Australian honey maker has been further seen to be in the joint venture with Comvita, with the immediate effect. This has been further seen to be based on the unrealized benefit from Queensland-based operations (Capilanohoney.com. 2017). The main reason for the preparation of the financial statement has been able to present the results of the financial position and the operations for the parent company. One more subsidiaries as if they are considered as an individual entity as it was a single company. Consolidation is seen to be necessary as the corporation own the majority of the stock for another corporation with the outstanding common stock management. The main form of the accounting principle has been applied with the preparation of the separate financial statements. It needs to be further considered that the individual company is seen to maintain individual accounting records. The parent company of Capilano had to prepare consolidated financial statements to be more useful in consideration of the individual financial transactions. The issued capital has included opening balance. The opening balance of the ordinary shares in 2017 has been further seen to be 9457481 valued at $ 24586831 for the parent company. The subsidiary of the company has been further seen to be considered as per the 8597121 shares valued at $ 8228220. The share issued has been further seen to be 860360 valued at $ 16777020. The closing balance of the shares has been further seen to be $ 24532156 with total of 9457481 shares. The subsidiary company has been seen to be having a share capital of $ 24586831 with total of 9457481 shares. It has been further identified to be owned by Capilano. It has been discerned that the published set of the financial report is not seen to reveal the policy on corporate governance, audit committees, solvency and sustainability. However, the company publishes the corporate governance documents in form of separate entities. Some of the main form of the corporate reports published by the company includes corporate governance statements, board charter, audit and compliance report, human resource and remuneration report of the common charter. Some of the various types of the other report of the company have been seen in terms of the inclusion of Honey supply and industry. Hence the company has considered all the aforementioned aspects in separate reports. Minority interest is that non-controlling interest (NCI), which has been identified with less than 50% of companys equity of another company. For the purpose of accounting, minority, the fractional share of the company has been seen be considered less than 50% of the voting tights. The minority interest is able to show the noncurrent liability stated in the balance sheet with the majority of the interest represented as proportion of its subsidiaries. This is seen to be owned by the minority shareholders. Some of the main form of interpretations from the annual report has suggested that the company maintains as separate entity hence it does not need to specify non-controlling interest. The goodwill is seen to be carried at cost, less the accumulated impairment losses. The Goodwill has been further seen to be calculated with the excess of the transfer of the acquisition date based on the fare value of the net identifiable assets. The Goodwill as per the acquisition of the subsidiary is further seen to be included in the intangible asset. The impairment of the goodwill and the intangible assets has been further seen to be considered as per indefinite lives of the assets. The company is not seen to be having any goodwill on 2017. The functional currency has been considered as per the consolidated entity has been further seen to be measured based on the currency in the primary economic environment in which the members are seen to operate. The consolidated financial statement has been further seen to be considered as per the monetary items and the same has been translated at the end of each year based on the exchange rate. The foreign currency items of the company are further seen to be translated at the end of each year and the non-monetary items are seen to be measured with the historical cost and carried at the exchange rate. At the end of the financial year it has been seen that the different type the consideration made for the disclosures for the directors and key management personnel is based on the remuneration disclosure. The main disclosure for the directoras and executives remuneration has shown cash salary and fees, various types of the non-monetary benefits, bonuses and the post employment benefits for the super-annuation. The contracts associated to the insurance are further seen to prohibit the disclosure and the nature of cover. The board has taken various initiatives for Continuous Disclosure Policy to ensure the compliance with the disclosures under the Corporations Act 2001 (Capilanohoney.com. 2017). On the aforementioned considerations it can be expected that all the issues have been resolved. If there is any other query kindly revert for further details. References Capilanohoney.com. (2017). [online] Available at: https://www.capilanohoney.com/uploads/Corporate/annual-reports/pdf/2016:Annual%20Report.pdf [Accessed 29 Aug. 2017]. Capilanohoney.com. (2017).Our Range. [online] Available at: https://www.capilanohoney.com/au-en/our-range [Accessed 29 Aug. 2017].

Monday, December 2, 2019

The Pros of Same-Sex Education Essay Sample free essay sample

Socially. same-sex schools are emotionally easier on pupils. Stereotypes based on gender are non a immense issue in these scenes. Girls are more vocal and competitory when male childs are non around to badger them. They besides feel more comfy take parting in athleticss and traditionally male dominated Fieldss when male childs are non watching. Conversely. boys become less competitory and join forces more because they don’t have to worry about girls’ sentiments of them. They can besides experience free to take part in the humanistic disciplines with a category full of other male childs. Advocates of same-sex schooling state this freedom builds assurance in immature pupils and allows them to concentrate on their surveies more because it removes the distractions of co-ed societal force per unit areas. Although really small research exists. some surveies have suggested that the benefits are more apparent in misss. lower income households and minorities. We will write a custom essay sample on The Pros of Same-Sex Education Essay Sample or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page Author Rosemary Salomone. argues that there is a topographic point for same-sex schools. In her book. Same. Different. Equal: Rethinking Single-Sex Education ( Yale University Press 2005 ) . she examines the benefits of single-sex instruction in the public kingdom. The Cons of Same-Sex Education Oppositions of same-sex schooling such as the ACLU and National Organization for Women have historically maintained that same-sex schooling would decrease the affects of Title IX [ â€Å"The Case for Single-Sex Schools† . The Christian Science proctor. Teicher. 2003 ] . Title IX. a 1972 Higher Education Act. calls for federally funded educational establishments to handle males and females every bit in schools and in athleticss. Some oppositions besides suspect that same-sex schooling will either push pupils into researching homosexual relationships. or on the contrary point of view. it could increase gender stereotypes and homophobia. As instructors. educational decision makers. and parents explore the educational benefits of same-sex schooling. arguments will go on to turn. If you are a parent observe how. when and where your kid learns best. Since each kid learns otherwise. your determination should be made on your child’s single demands. The best educational scene fo r your kid may really good be a same-sex school or category. Twenty old ages ago. theoretical accounts weighed 8 % less than the mean adult female. Today. they weigh 23 % less than the mean adult female. The mean American adult female is 5’4† tall and weighs 140 lbs. The mean American theoretical account is 5’11† tall and weighs 117 lbs. If Barbie was a existent adult female. she’d have to walk on all 4s due to her proportions. Approximately 7 % of 12th class males have used steroids in order to go more muscular. If GI Joe were human. he’d have larger biceps than any muscle builder in history. One out of every four college aged adult females has an eating upset. It is estimated that 40-50 % of American adult females are seeking to lose weight at any point in clip. Americans spend more than 40 billion dollars a twelvemonth on dieting and diet-related merchandises – that’s approximately tantamount to the sum the U. S. Federal Government spends on instruction each twelvemonth! Almost half of all adult females tobacco users smoke because they see it as the best manner to command their weight. Of these adult females. 25 % will decease of a disease caused by smoke. In 2007. there were about 11. 7 million decorative processs performed in the U. S. Ninety one per centum of these were performed on adult females. A survey found that 53 % of thirteen-year-old American misss are unhappy with their organic structures. This figure grows to 78 % by the clip misss reach 17. Despite the demand of international jurisprudence that prison should be a last resort for kids. kids every bit immature as 12 can now be jailed. if they commit an offense which would be punishable by prison if committed by an grownup. Following the Crime and Disorder Act of 1998. the Home Secretary has the power to take down the age of detainment to 10 old ages old. What offenses are they sentenced for? About half the kids in prison have been convicted of non-violent offenses. More kids are in prison for robbery than any other offense ( 3 ) . Sentencing for kids is going harsher – in 1992 merely 100 kids under 15 were sentenced to detention. all had committed what were defined as ‘grave crimes’ . In 2003/4 794 under 15s were imprisoned. yet merely 45 of these had committed the same definition of ‘grave crimes’ . ( 4 ) How much does it be? It costs ?50. 800 per twelvemonth to direct person to a Young Offenders Institution. ?164. 750 to direct a kid to a Secure Training Centre and ?185. 780 to put a kid in a Local Authority Secure Children’s Home ( 5 ) . Are they safe at that place? 29 kids have died in province detention since 1990. most ego inflicted but one following restraint ( 7 ) . Adam Rickwood became the youngest kid to decease in penal detention at the age of 14 in August 2004. There has neer been a public enquiry into any of these deceases. Does it work? Reconviction rates are highly high for kids. Over eight out of 10 male childs under 18 who were released from prison were reconvicted within two old ages. ( 8 ) What sort of kids are in prison? Of those in detention of school age. over one in four has literacy and numeracy degrees of an mean seven twelvemonth old. Over half of under 18s have been in attention and about half have been for good been excluded from school ( 9 ) Of captives aged 16-29. around 85 % show marks of a personality upset and 10 % exhibit marks of psychotic unwellness e. g. schizophrenic disorder ( 10 ) . Over half of 16-20 twelvemonth olds who are locked up say they were dependent on drugs or intoxicant in the twelvemonth prior to imprisonment ( 11 ) One in three misss have been subjected to sexual maltreatment. and one in four haveexperient force at place. ( 12 ) Merely over one in three immature people who are locked up say they have felt insecure at some clip in their detention. ( 13 ) Young people ( 18-20 twelvemonth olds ) in prison There are 8. 658 immature people in prison ( 14 ) In the last 10 old ages the figure of sentenced immature grownups come ining prison has increased by 40 % and the figure of sentenced immature adult females imprisoned has about trebled. ( 15 ) How long are they there for? Two tierces are sentenced to less than 12 months in detention. The mean clip spent in detention for immature grownup captives is merely over 8 hebdomads. ( 16 ) How far are they from place? One in three are held more than 50 stat mis off from place. one in four are held between 50 and 100 stat mis off and one in 10 are held over 100 stat mis off. ( 17 ) What kinds of immature grownups are in prison? 75 % of those held in immature offenders’ establishments have non attended school beyond the age of 13. Just under 1/3 have basic accomplishments shortages ( compared to ? aged 25 and over ) . About ? were excluded from school at some phase. and 2/3 were unemployed at the clip of their apprehension. ( 18 ) Mental wellness jobs and drug and intoxicant maltreatment are common amongst immature people in prison. They are more likely than grownups to endure from mental wellness jobs and more likely to try or perpetrate suicide than both older and younger captives. ( 19 ) What happens to immature people after they leave prison? The Chief Inspector of Prisons estimated that one in five immature captives had no thought where they would populate on release. ( 20 ) Does it work? Re-conviction rates are peculiarly high for immature people. About 8 out of 10 immature work forces released from prison in 2002 were reconvicted within 2 old ages of release. ( 21 ) Who else is affected? It is estimated that one in four immature male wrongdoers are male parents and four in 10 immature females are female parents ( 22 ) What’s the best manner to cut down piquing? Alternatively of constructing more prisons for immature people. the authorities should put in undertaking the causes of their offending by supplying:†¢ More constructive activities for immature people†¢ More support to better parenting†¢ More mental wellness. drug and intoxicant intervention in the community†¢ Improved community penalties where immature wrongdoers do mandatory work to pay back for the harm they have caused

Wednesday, November 27, 2019

Accordig To The Requirement In The File Example

Accordig To The Requirement In The File Example Accordig To The Requirement In The File – Assignment Example number The Starting Point And Scattering Of Anatomically Modern Homo Sapiens It is now known that anatomically modern Homo sapiens originated from Africa, and then dispersed to Europe and Asia. This discovery does come with evidence, and there have been different models explaining how the dispersal took place, and why researchers and archaeologists have come to a conclusion that these anatomically modern Homo sapiens came from Africa. One of such models is explained by Mellars who indicates that there are two explanations to the origin and dispersion. The first possibility is that the anatomically modern Homo sapiens moved from Africa through North Africa and the Nile Valley, then dispersed to the East Asia and west Europe. The second possibility through which they dispersed to Asia and Europe is from Ethiopia, across that edge of the Red Sea, moving eastward along the South Asian coastline, or northward through Arabia.Current evidence showing such origin and dispersal are from Mitoc hondrial DNA analysis coupled with archaeological findings in Africa. Currently, Mitochondrial DNA lineage analysis strongly supports the second hypothesis about the dispersal of this anatomically modern Homo sapiens. The analysis indicates that it is only the L3 lineage members that dispersed from Africa. The lineage then diversified into N, M, and R derivative lineages. These are commonly found in modern Asian populations, but they diversified into Southern Asia and Malaysia at least 50,000 Before Present and 65,000 Before Present respectively. Studies on the Y chromosome also reveal similar conclusion. This only means that the anatomically modern Homo sapiens dispersed into Europe and southwest Asia through western or central Asia (Mellars). Work CitedMellars, Paul. Why Did Modern Human Populations Disperse From Africa ca. 60,000 Years Ago? A New Model. PNAS, 105 (25). Web.pnas.org/content/103/25/9381.long

Saturday, November 23, 2019

Vortigern - Early British Leader

Vortigern - Early British Leader This profile of Vortigern is part ofWhos Who in Medieval History   Vortigern was also known as: Guorthignirnus, Gurthrigern, Wyrtgeorn Vortigern was noted for: Inviting the Saxons to help him fight northern invaders, essentially opening the door to a significant Saxon presence in England. Occupations Roles in Society: KingMilitary Leader Places of Residence and Influence: England Important Dates: Declares himself High King of Britain: c. 425Dies: c. 450 About Vortigern: Although many legends have sprung up concerning Vortigern, he was probably an actual historical figure. He is mentioned in On The Ruin of Britain, History of the Britons and the Anglo-Saxon Chronicle. In the uncertain decades following the withdrawal of Roman troops from Britain, Vortigern emerged as a strong leader of the Britons, and dared to declare himself High King. When he faced attacks by Picts and Scots in the north, he followed a common Roman imperial practice: he invited Saxons to come to England to fight the northern invaders in return for a grant of land. This reportedly did not go over very well with most of the British, who disliked sharing their lands with Saxon interlopers, and things got worse when the Saxons rebelled and fought against Vortigern. According to the Historia Brittonum, the rebellion ended when the Saxons killed Vortigerns son Vortimer and massacred many British nobles. Vortigern subsequently granted the Saxons lands in Essex and Sussex, where they would build kingdoms in the coming decades. Vortigerns role in facilitating Saxon access to England was remembered with bitterness by British chroniclers. Scholars using British sources to understand Vortigern must take great care in evaluating them, especially when those sources were created several centuries after the events in question. More Vortigern Resources: Post-Roman Britain: An Introduction   Vortigern on the Web A Clerical Portrait of Vortigern?An examination of the recorded view of Vortigern by Michael Veprauskas at the Early British Kingdoms website.The Vortigern Studies HomepageAn initiative based in the Netherlands, dedicated to the study of the period between the Roman occupation of Britain and the Early Middle Ages Dark-Age Britain Whos Who Directories: Chronological Index Geographical Index Index by Profession, Achievement, or Role in Society The text of this document is copyright  ©2007-2016 Melissa Snell. You may download or print this document for personal or school use, as long as the URL below is included. Permission is  not  granted to reproduce this document on another website. For publication permission,  please  contact  Melissa Snell. The URL for this document is:http://historymedren.about.com/od/vwho/p/who_vortigern.htm

Thursday, November 21, 2019

Change Management and Motivating People to the Change Dissertation

Change Management and Motivating People to the Change - Dissertation Example Organizations are every other day putting efforts to bring a positive alteration in their organization to survive in this competitive corporate world (Ventris, pp. 11-19, 2004). In addition, as there have been huge numbers of advancements in the field of information and technology, organizations are now feeling greater pressure in midst of globalization that has inclined organizations to introduce new methodologies, take innovative approaches, and inspire new perspectives in their workforce. In this process of constant change, experts have indicated that managers, especially HR managers play the most crucial role in ensuring success in the process of change in organization. At the same time, besides ensuring success, managers have to fulfill the greater responsibility of avoiding any adverse effects of the process, and simultaneously, ensure motivation of the employees. Unfortunately, huge numbers of organizations seem to fail in this process of ensuring success, and at the same time, continued motivation of employees that has been resulting in lower productivity, adverse performance, and subsequently, failure of the organizations. From this understanding, one can see only two ways of ensuring survival in this harsh competitive business world. Firstly, organization can become an initiator of the change and become a leader. On the other hand, one can act as a follower and carry out alterations depending on the approaches of market leaders. (Kossmann, pp. 39-44, 2006). In particular, there is no other way of bringing a change, and thus, realization of such notion is essential along with understanding of different factors that play the role in the process. Research Statement In this regard, the researcher focused on the following research statement to acquire the aims and objectives of the research: â€Å"To identify and analyze barriers to change and motivation process causing failure in the organizational management, particularly, in context of Middle Eastern organization† Aims & Objectives From this understanding of process of change, the researcher has identified a few aims and objectives that will enab le a critical, clear, and comprehensive understanding of the change process. In particular, the main aims and objectives of this research are to: Recognize and analyze various physical, sociological, and physiological barriers that exist and affect in the process of change in the organisation Scrutinize the level of impact of identified barriers on employees’ performance and their level of motivation Assess the impact of identified barriers in employees’ decision-making processes that play a crucial role in the success or failure of an organization Evaluate the role of managers in recognizing barriers, and in reducing the chances of failure in the organizational management Identify approaches and solutions that can ensure effective change and motivation processes in the organizatio

Tuesday, November 19, 2019

South Australian Curriculum Framework Essay Example | Topics and Well Written Essays - 2250 words

South Australian Curriculum Framework - Essay Example This paper declares that the analysis of â€Å"R-10 English Teaching Resource† document is especially interesting from the view of an ESL learner as there are some mismatches in this particular part. The key decision makers about these mismatches are teachers who critically evaluate the document and make correct decisions on further teaching and learning development: â€Å"Thus, the teacher can learn the purpose of their learning a language, their favorite / least favorite kinds of class activities, and the reason why they learn a language†. This essay stresses that there are some key-point factors shaping the curriculum in the context. The first one is critical analysis of texts – it is a very important part of working at texts and allows understanding contexts. The second one is convenient modes sectioning of the curriculum document. This curriculum shaping factor allows learners to study English in complex and divide learning process into appropriate parts. The third one: the document â€Å"provides examples of content at particular levels, while not constraining the possibilities to these examples†. The critical analysis of the document allows viewing it from different sides – it is rather useful for making appropriate decisions for improving the English language curriculum for ESL students not only in South Australia, but also in other regions and countries. The document key aspects of languages education is the first item to be observed.... Appropriate skills and knowledge levels shape the learning context of the curriculum by further language skills improvement practice of learners, and this process is well reflected in the document.The critical analysis of the document allows viewing it from different sides - it is rather useful for making appropriate decisions for improving the English language curriculum for ESL students not only in South Australia, but also in other regions and countries. The document key aspects of languages education is the first item to be observed. The focus age group is 7 - 17 years old learners of primary schools, including ESL learners of the same age. The main ESL context of the document is connected with the learners' work on texts, their structure, analysis and their cultural context. So, the document provides such learning context for ESL learners. It has a variety of different learning activities relevant to ESL learning context, as will be indicated below.2. The purpose of the document "R-10 English Teaching Resource" is help for teachers in SACSA Framework application in teaching and learning process: "These resources are designed to support teachers to engage further with the SACSA Framework and work towards maximising students' achievement. They arise from the need expressed by many teachers for the requirements of the SACSA Framework to be made more explicit for each year level" (R-10 English Teaching Resource). The targeted group to use the document is a group of teachers who want to develop their personal teaching and learning programs. The document has concept maps which underline basic items concerning listening, speaking, reading, viewing and writing. "R-10 English Teaching Resource" document also

Sunday, November 17, 2019

Barack Obama and his Political Propaganda Essay Example for Free

Barack Obama and his Political Propaganda Essay The process of running for the United States presidency is no easy task. Like in almost any relationship, attraction is the key to provide the foundation for anticipation and expectations. In the beginning, one will always place his best foot forward, and contemplating on addressing issues which would appeal dramatically to other people. Running for the presidency is no less than different with pursuing a girl to have a relationship with you. It all starts with making her pay attention to what you have to say and to what you can offer despite many competitors.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Barack Obama came across the attraction stage with flying colors because he seemed to have captured the attention of most population in the American community, across varying groups and minorities (Martin, 2008, p.1). For one, he appeared to come prepared for what is known as a great battle to get Democratic nomination against Senator Hillary Clinton who is one tough competitor. Obama lacks the experience, and can be said as less popular than Clinton who has established her prominence during the presidency of her husband. However, the appeal in Obama’s candidacy defers the idea that he was only elected as Senator in 2005, and a very young player in the realm of politics.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   This paper aims to explore the political propaganda used by Obama to ensure his future in the White House. For the purpose of the paper, we shall examine the different types of media used by Obama to gain votes and preferences, the manner by which he delivers his agendas, his target audience and supporters, and how this greatly affects his stance in the race to get the democratic nomination. It is certain that the race between Obama and Clinton’s nomination is very tight, but we shall take the time to assess how Obama’s political propaganda has delivered expected results in his leads on major polls and surveys worldwide as Democrats most preferred candidate. â€Å"Change we can believe in† It is a fact that most Americans are demanding change from future politicians in running the country. Many circumstances and events has led Americans hopeful for change and has been the pivotal driving force behind many political agendas. Obama is no exception. By using the ideology of â€Å"change† as a campaign slogan, he ignites the hope among idealistic men and women around the country to believe in what he regards as change (Obama 2008: Change we Believe In, 2008). Obama has a great advantage in speaking with eloquence and sensitivity, with emotions that has words fulfilled with hope and change, gives many people the self-identity they want to see change in the future administration, or in this case, in a democratic candidate for the presidency. This is a note worthy to be taken beforehand, so as to provide a basis on how we can assess Obama’s political propaganda.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Even before the decisive voting held on February 5, 2008, there has been a pronounced shift in favor for Obama of Illinois from opinion polls, surveys, campaign contributions and political and media endorsements (Martin, 2008, p.1). Obama, being a new player in the realm of politics used significant intervention from different political representatives to endorse his candidacy. For example, when Senator Edward Kennedy expressed his fervent support for Obama, it has generated significant contribution in uplifting Obama’s candidacy. As many critics saw it, Kennedy’s endorsement has become a signal of the Democratic Party’s consensus on his candidacy. Following this influential event led to many mass media endorsements of the event including newspapers published in California, Los Angeles Times and La Opinion, which the most widely-read Spanish-language daily.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   After Kennedy’s endorsement, opinion polls showed Obama in strict ties with Senator Clinton for the democratic nomination (Associated Press, 2008). The strategy used governs many political advisers view to gain majority of delegates from key states to secure victory, and Obama did it with just one major political and highly-publicized endorsement.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   The appeal of Obama’s political propaganda can be deemed into two significant standpoints. First, the on-going deep desire for social and political change is strongly used by the Obama campaign to hub an illusion, and to foster great support from the idealist (martin, 2008, p. 1). This s highlighted by the mass media by emphasizing that this change will come from someone from the African American community, a fundamentally groundbreaking event in American history if and when Obama wins as the first black President. However, Obama is not a clear product of any acts against racial oppression and civil rights struggles. He is a politician groomed to be of appeal to massive voters in the coming elections.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Obama’s political propaganda seeks to disengage and disassociate itself from the struggle of the elite and ruling class in running the country. More so, the critiques on Obama has seemingly less impacts because of a well-organized activities from the media who supports his candidacy and owes their respective professions to corporate bosses and financial institutions which have their own candidate as preferences. Even Obama’s appeal has penetrated the right-wing group with endorsements from Rupert Murdoch for example.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   Also significant of the character of Obama’s political propaganda is the shift in campaign contributions from major business firms. More money means more capability in a candidate’s political machinery. Obama has been endorsed by different military institutions, then national security adviser to President Jimmy Carter, Zbigniew Brzezinski, and Warren Buffett, the second richest man in the United States. Other known mass media executives and corporate executives have also pledged significant amounts for Obama to continue his aspiration on the America presidency. Through continuous efforts from the Obama campaign wagon to instill their dedication towards real change, the Los Angeles Times broke their tradition of not endorsing any candidate with the promotion of Obama’s candidacy in their editorial (Martin, 2008, p.1 ).   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚     As an observation, although generally the political propaganda of Obama is sufficient for him to gather and maintain support, it is also clear with biases to achieve voters support. For one, it sometimes resorts to Ad Hominem or the attack to his primary opposition and her arguments. In many cases, through debates and news reports, Obama responds to what Clinton offers on a negative tone. Although at times he emphasized their differences, he also had made several points of their similarities obvious to other people. By using change as a promotional concept and advocacy of his candidacy, he often appeals to authority which uses an ideal which is popular amongst people and grant their support for the ideology he used. He also often uses the appeal to prejudice on many public conventions and speaking engagements to evoke the sense of emotional value and goodness to benefit his character. Conclusion The Obama campaign has utilized effective marketing campaign strategies which efficiently used their connections and endorsements form media outlets and institutions. For the most part, Obama is following a political propaganda which is embedded to deny political differences and social classes but with emphasis on the economic differences between individuals in the society.   Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚   The Obama political propaganda strongly used news reports, radio, television and posters. It specifically and strategically used these media to indoctrinate various groups of audiences he wished to communicate with and to. Usually through this media, Obama used a directional method on how people can learn about more of his strategies, goals and principles. Through these methods, he intends to initiate individuals as information seekers, to recipients, to reinforcement and opinion leader in favor of his own. Works Cited: Associated Press (2008). â€Å"Obama comes up short on union support.† Hemscott Group Limited. Retrieved on March 24, 2008, from http://www.hemscott.com/news/latest-news/item.do?newsId=56416543358904 Martin, Patrick (2008). â€Å"US political establishment lines up behind Barack Obama.† International Committee on the Fourth International (ICFI). Retrieved on March 24, 2008, from http://www.wsws.org/articles/2008/feb2008/obam-f04.shtml Obama for America (2008). â€Å"Obama 2008: Change we Believe In†. The Official Site of Obama’s Campaign. Retrieved on March 24, 2008, from http://www.barackobama.com/

Thursday, November 14, 2019

Year Round Schooling Speech -- Education

Year Round Schooling Speech Have you ever thought about what life would be like having to go to school year round? Well kids today feel that with all the pressure and work they have during the school year, they need the 3 month break time period in order to regroup themselves and have a change of scenery. Year round schooling in the past few years has become a trend that is sweeping the nation, and I am going to tell you why year round schooling IS NOT a way to send the children of America through school. Not only does year round schooling affect the children of America but, it also affects the parents of students, the personal growth and maturity of the students, and the experiences that each child should encounter in-order to develop their own self. Year round schooling affects the parents of students almost as much as the student themselves. Now, I know you guys are thinking, how does this affect parents when we are the ones actually going to school? Well according to the American School Board Journal, parents "turn thumbs down" to year round schooling. Parents...

Tuesday, November 12, 2019

Furman Selz

The firm had a unique approach to everything – from hiring employees, selecting clients to providing services. As the firm grew in size and in revenues, its founders realized the need for professional management. This brought about the very first change – in form of Edmund Hails. With a highly structured and consistent approach, Hajji set out to re-form the entire system and expand the company with the help of Steve Belcher, COO.The new P&L's (Profit ; Loss system) and Compensation system were Ingredients of this change management process. During the acquisition process, Farman Sell witnessed drastic culture hinges from the Orlando Clan culture to a Bureaucracy one. Farman Sell was acquired by Xerox Financial Services Inc. In 1987. On one hand, the people of Farman Sell were put-off by the bureaucratic style and on the other hand, the firm enjoyed being under the umbrella of a big brand.Following the ‘Black Monday' of 1987, the financial services sector was badly hit and even though the performance of Farman Sell was above average, Xerox decided to sell its financial services unit and once again, Farman Sell became a private company owned by the firm's management and a group of employees. Edmund Hajji took over the reins and quickly distributed company stocks to key employees in order to retain them. The firm then focused on aggressive hiring of new talent and expansion of Its business.Farman Sell became a very sought-after company to work with. In 1995 the Federal Reserve relaxed the Glass-Steal regulations, which had emerged as a way to control the banking industry after the Great Depression. Then there were few restrictions when commercial banks want to combine with security business and vice versa. As a result, many mid-sized investing banks were looking to merge with larger rims and therefore attain growth and the possibility to participate in larger deals.As business grew across various dimensions, Farman Sell realized that they were à ¢â‚¬Ëœt competitive and they lost a lot of deals because of smaller size of the firm, limited equity and the businesses that were increasingly becoming global, especially when there was huge growth In mergers and acquisitions. This Is when INNING Barings acquired Farman Sell, pursuing an international expansion strategy in both banking and Insurance. The acquisition made by INNING shows clear failures in the 3-Stages Model of Merges and Acquisitions.In the first stage, â€Å"Pre-Combination†, there Is a lack of the cultural assessment needed by the HRS department. It Is needed to evaluate the philosophies and values of both companies, and therefore understand among toners, ten learning styles, relative value AT stats Consolers or ten value AT teamwork versus the individual performance and recognition. Thus, it would be easier for both companies to develop a plan for managing the process of the M;A. In the INNING case, there seems to be a lack of this pre-combination assessmen t, in that the company wanted to climb up the rankings without investing more money.They din ‘t understand that the company the day before the acquisition was the same as the day after. INNING Barings had most of its business in commercial banking and insurance, with absolutely no business lines in areas of Investment banking. Almost immediately, tension started developing between managers of INNING Barings and Farman Sell because there were differences in agreement on key business issues. The complexities in structure of INNING were not taken well by former Farman Sell employees.Regarding the second stage, â€Å"Combination-Integrating the Company', there are several decisions that would help n the process of the acquisition. Firstly, there was no integration manager, who is a key person – not in running of the business, but in attaining a higher percentage of retention of the acquired managers and key employees and at the same time in achieving the business goals ear lier. Second, INNING group decided to have 2 co-leaders in the new company and this created confusion. The workers felt that they din ‘t understand the expectations that INNING had.In order for a M&A to succeed, it is necessary to have a strong leader who can manage the new business combination ND avoid uncertainty, lack of direction and the adjournment of important decisions. In this second stage, clear and positive communication is extremely important. It is also necessary to identify key employees and develop the incentives process in order to retain them. It is evident that INNING did not realize the importance of investing time and money into the newly formed relationship with Farman Sell resulting in failure to achieve common ground while making business decisions.Lack of communication usually leads to confusion, reduced productivity, a high level of uncertainty and low morale. The situation was worsened by the departure of key management personnel, one after the other, in a very short span of time. The problem can be attributed to poor integration post acquisition. It seems that INNING understood who the key players were, and positioned them in different departments, such as Steve Blob (Research), Bill Shutter and Chris Moore (Corporate Finance), who along with Bill Torsos were called the â€Å"troika† and developed a new incentive system to ease the complexity created.The problem arose when as a consequence of the Russian debt crisis, only a small number of top performers received bonuses and most of other employee din t receive anything, even though INNING Barings had no part in the Russian problem. As a result of pessimism and the problems with bonuses, many talented people left the company. Statistics reveal that about 70-80% of mergers fail to provide value to the company. The people driving the business are the single most important factor determining the success of a merger or acquisition and this fact cannot be ignored.The 6th Princ iple for Managing Change shows us the importance of the different stakeholders in the company when it under goes changes. The company needs to understand who are these key stakeholders and prioritize them. While the senior management of Farman Sell was supporting the acquisition there were many employees across several levels of management that fold under the category of Skeptics. I nose are ten people winos n seas nave to De reassess Tort smooth transitioning. Looking at the Change Curve we see several reactions of employees of Farman Sell – from initial shock to denial and anger.It is evident from the fact that people felt betrayed when they realized that they were ;t going to be an independent subsidiary. At the same time, HRS personnel at Farman Sell were not forth coming in haring information, because they were angry at how things had been handled. Finally, everything led to Depression, when a lot of key employees left the company. If INNING had invested sufficient money and effort towards smooth integration, the curve could follow the intended path to acceptance, discovery and integration.Now that Farman Sell has already been acquired by INNING Barings, we strongly recommend that INNING invests additional funds as well as effort for a smooth integration and sustainability. This includes looking into various issues: * Management issues * Talent recruitment, compensations and rewards Alignment of HRS policies * Defining a vision for the newly acquired company * Identifying procedures that work well with both parties * Identifying cultural barriers to progress In addition, internal communication is also a critical tool.A seamless communication will ensure that people do not become pessimistic and lose confidence. It will reassure employees and instill a greater sense of belonging. In cases of M & A, involving cross-border deals, cultural differences, legislative complexities, local know- how and ways of doing business all provide obstacles to smooth transitioning and progress. A lot more sensitivity is required when affecting such deals – both pre acquisitions as well as post-acquisition.For example, the newly formed teams may face inter-personal conflict and not be clear about its responsibilities and goals. Ideally, post an acquisition, efforts should be made to allow the acquired firm retain its best management practices and values that are important to its managers. This will help create greater harmony in operations. In addition, a feedback taken from different levels of management can help identify problem areas and allow senior managers find ways to resolve them.

Sunday, November 10, 2019

Immanuel Kant Essay

Introduction 1What does philosophy mean? -Everyone has a philosophy -We have ideas concerning things, people, the meaning of life, death, God, what is good and bad. -We may have certain attitudes to life, certain ways of looking at things. -For example: -I am an optimist. I can always see a positive side to most unhappy situations. -I don’t believe in worrying too much. I think about today. Tomorrow can take care of itself. -Although an individual claim this to be his philosophy and rightly so. But this is not philosophy as a discipline. It is too broad, vague, superficial, impersonal and unclear. It does not adequately describe the work of a philosopher. -We need to define philosophy more specifically. 2The word â€Å"philosophy†. -The Word â€Å"Philosophy†. -Philia (love) + Sophia (wisdom) = the love of wisdom. 3Definitions of philosophy a. The study of the nature and meaning of the universe and of human life Online Oxford Advanced Learner’s Dictionary. b. Philosophy is a rational attempt to look at the world as a whole. 4What does philosophy seek to do? -Philosophy seeks to examine fundamental questions about the universe and about ourselves with the hope of coming up with consistent principles by which we can understand and live. 5Human beings have always sought answers to certain fundamental questions – What are these fundamental questions? -What makes an action write or wrong? -What is my purpose in the world? -What is truth? -What makes a good life? -Is God important in our lives? -Where does knowledge come from and how do we know that our knowledge is true. -What is the relationship between mind and body? 6Why do we need philosophy? Why do we need philosophy when we have science and technology? -We have advanced so much in science and technology -We live in cities, we have conquered the air and have ventured into space? -Communication is so developed that distance no longer matters -We have immense power over nature -We are able to produce more goods and services than ever before -So, why do we still need philosophy? 7Yet all these advances cause us to be disturbed and anxious -There is a danger that the very technology we have developed could destroy us. -For example nuclear technology. -We seem to be unable to deal with the problems of war, famine, terror, distribution of wealth, pollution, the threatened extinction of wildlife, exploitation and oppression of the weak . -Knowledge and values appear to be divorced. -This is where philosophy comes in. It helps us to examine our lives as individuals and groups. -Philosophy may not be able to provide solutions to all the world’s problems. But it helps to examine issues clearly, consider options and help us to make informed decisions. -With poor, incomplete and shallow reasoning we cannot build an enlightened society -If we are unable to distinguish between valid and invalid reasoning, then we become victims of persuasive orators, cult leaders and unscrupulous political leaders. -Philosophy helps us to see more deeply and clearly into an issue. It helps us to question traditional and outdate beliefs so that we can make informed choices -Knowledge of ethical systems help us to live ethical lives at the personal and communitarian level. -Knowledge of what constitutes beauty helps us to appreciate and respect differences in individual and cultural concepts of beauty and art. -Being able to think critically will help us to be aware of any irrational and oppressive beliefs in religion. 8The traditional divisions of philosophy. a. Logic b. Metaphysics c. Epistemology d. Value Theory LOGIC aLogic. -The systematic study of rules to distinguish or recognize good arguments from bad. -In an argument, groups will give opposing views. -How do we know which argument is good and which is not good. -Logic helps us to do so by providing rules to recognize right argument from wrong argument. -It is concerned with tests to find out which arguments are valid. -Logic runs through all the other branches of philosophy. METAPHYSICS -bMetaphysics The study of the nature of being and of the world. -It is concerned with the fundamental nature of all reality, both visible and invisible. -It asks what reality is, why it is, and how we can understand it. Ontology That part of metaphysics that studies being or existence. EPISTEMOLOGY cEpistemology The study of the sources, nature and validity of knowledge. -It deals with issues like: -What are the sources of knowledge? (Origin of knowledge) -Where does genuine knowledge come from? -How do we know? -What is the nature of knowledge? (Appearance and reality) -Is there a real world outside the mind? -If so, can we know it? -Is our knowledge valid? (Truth/Verification) -How do we distinguish truth from error? Two traditional schools of thought have sought to answer the questions above: -Rationalism -Human reason alone can discover the basic principles of the universe -Empiricism -All knowledge ultimately comes from sense experience, and therefore our knowledge is limited to what can be experienced. There is a relationship between metaphysics and epistemology. Our understanding of reality (metaphysics) depends on our understanding of what can be known (epistemology). Our theory of knowledge (epistemology) depends on how we understand ourselves in relation to the whole of reality (metaphysics). VALUE THEORY dValue Theory The branch of philosophy that studies values. -It can be subdivided into ethics, aesthetics, and social and political philosophy. iethics: is concerned with morality; right or wrong behavior. -the three areas of ethics are : descriptive, normative and metaethics. -descriptive ethics (what is ) identifies motives, desire and intentions of human conduct and acts. It describes moral actions. -normative ethics (what ought to be) proposes the principles by which people ought to act and live. These are called ethical theories. – – -Meta-ethics(analysis) on how we understand, know about, and what we mean when we talk about what is right and what is wrong. It deals with the meaning of key concepts, techniques of reasoning and analysis, and linguistic conventions It deals with matters like what do moral terms mean? What sort of mental state is involved in accepting a moral claim – a belief, an emotion? Is there any sort of moral reality or facts? Is ethical knowledge attainable? If so, how? In fact, drawing the conceptual distinction between Metaethics, Normative Ethics, and Applied Ethics is itself a â€Å"metaethical analysis. † ii. Aestheticsis concerned with the theory of art and beauty. -Many philosophical problems in aesthetics involve critical judgements.? -It deals with concepts of concepts of beauty. Is beauty subjective or objective? iii. Social and political philosophyisconcerned with value judgments concerning society, the state and the individual’s relation to these institutions -It deals with issues like -Why should individuals live in society? -What should be the social ideals of liberty, rights, justice, equality and responsibility -Why should anyone obey any government? -Why should some individuals or groups have political power over others -Who should have political power over others? -What should the scope of political power be? -What are the goals of government? Glossary 1philosophyphilia (love) + Sophia (wisdom) = the love of wisdom 2logicThe systematic study of rules to distinguish or recognize good arguments from bad 3metaphysicsThe study of the nature of being and of the world 4epistemologyThe study of the sources, nature and validity of knowledge 5value theoryThe branch of philosophy that studies values. It can be subdivided into ethics, aesthetics, and social and political philosophy. 6rationalismHuman reason alone can discover the basic principles of the universe 7empiricismAll knowledge ultimately comes from sense experience, and therefore our knowledge is limited to what can be experienced 8aesthetics Is concerned with the theory of art and beauty.

Thursday, November 7, 2019

Pay Structure for Teachers essays

Pay Structure for Teachers essays The teachers salary schedule relays that they are paid on a knowledge based pay structure. Even though for every year you teach with out advancing your education your pay increases. It increases even faster when you advance your education to a higher level. To change this to a more person based pay structure take the skill that the teacher is proficient in and evaluate how well they transfer what they know to the students. Also evaluate their competency how well does the teacher perform his/her methods and the structure of the class. Evaluate if the teacher is involved with any extracurricular activities for example clubs and sports for the school to show pride in where they work. Also take a look at the teachers certificates has the teacher performed the requirements of schooling for that field, has the teacher made themselves more knowledgeable on the subject they are teaching, and have they made any other effort to further advance their learning in the field in which they ar e working. As of now the pay structure for a teacher is definitely a knowledge-based structure, but it could easily be transformed into a person based structure with a few minor adjustments. The message relayed by the increasing differentials is that the more education you have the better off your pay will be down the line. At MA+60/PHD and 15 years of teaching acquired will be higher than a teacher with just 15 years of teaching and no credits acquired for furthering education. It will also interest the teachers in going back to school to further their knowledge among the field they are teaching in so that they will get a more substantial increase in the future years they work. The knowledge-based theory is a perfect description of this stepped salary. The more you know the more you get paid. They want to motivate to learn more to better educate. Some teachers may feel this a threat to their job. The elders in ...

Tuesday, November 5, 2019

Lockheed F-104 Starfighter History

Lockheed F-104 Starfighter History The Lockheed F-104 Starfighter was developed for the US Air Force as a supersonic interceptor. Entering service in 1958, it was the USAFs first fighter capable of speeds in excess of Mach 2. Though the F-104 set a multitude of airspeed and altitude records, it suffered from reliability issues and possessed a poor safety record. Briefly used in the Vietnam War, the F-104 was largely ineffective and was withdrawn in 1967. The F-104 was widely exported and saw service with numerous other countries. Design The F-104 Starfighter traces its origins to the Korean War where US Air Force pilots were battling the MiG-15. Flying the North American F-86 Sabre, they stated that they desired a new aircraft with superior performance. Visiting American forces in December 1951, Lockheeds chief designer, Clarence Kelly Johnson, listened to these concerns and learned firsthand the pilots needs. Returning to California, he quickly assembled design team to begin sketching out a new fighter. Assessing several design options ranging from small light fighters to heavy interceptors they ultimately settled on the former. Building around the new General Electric J79 engine, Johnsons team created a supersonic air superiority fighter that utilized the lightest airframe possible. Emphasizing performance, the Lockheed design was presented to the USAF in November 1952. Intrigued by Johnsons work, it elected to issue a new proposal and began accepting competing designs. In this competition, Lockheeds design was joined by those from Republic, North American, and Northrop. Though the other aircraft possessed merits, Johnsons team won the competition and received a prototype contract in March 1953. Development Work moved forward on the prototype which was dubbed XF-104. As the new J79 engine was not ready for use, the prototype was powered by a Wright J65. Johnsons prototype called for a long, narrow fuselage that was mated with a radical new wing design. Employing a short, trapezoidal shape, the XF-104s wings were extremely thin and required protection on the leading edge to avoid injury to ground crews. These were combined with a t-tail configuration aft. Due to the thinness of the wings, the XF-104s landing gear and fuel were contained within the fuselage. Initially armed with a M61 Vulcan cannon, the XF-104 also possessed wingtip stations for AIM-9 Sidewinder missiles. Later variants of the aircraft would incorporate up to nine pylons and hardpoints for munitions. With construction of the prototype complete, the XF-104 first took to the sky on March 4, 1954 at Edwards Air Force Base. Though the aircraft had moved quickly from the drawing board to the sky, an additional four years were required to refine and improve the XF-104 before it became operational. Entering service on February 20, 1958, as the F-104 Starfighter, the type was the USAFs first Mach 2 fighter. Cockpit of a F-104C Starfighter. US Air Force Performance Possessing impressive speed and climb performance, the F-104 could be tricky aircraft during takeoff and landings. For the latter, it employed a boundary layer control system to reduce its landing speed. In the air, the F-104 proved very effective at high-speed attacks, but less so in dogfighting due to its wide turning radius. The type also offered exceptional performance at low altitudes making it useful as a strike fighter. During the course of its career, the F-104 became known for its high loss rate due to accidents. This was particularly true in Germany where the Luftwaffe grounded the F-104 in 1966. F-104G Starfighter GeneralLength:  54 ft., 8 in.Wingspan:  21 ft., 9 in.Height:  13 ft., 6 in.Wing Area:  196.1  sq. ft.Empty Weight:  14,000 lbs.Loaded Weight:  20,640 lbs.Crew:  1Performance Power Plant:  1 Ãâ€" General Electric J79-GE-11A afterburning turbojetCombat Radius:  420 milesMax Speed:  1,328 mphArmament Guns:  1 Ãâ€" 20 mm (0.787 in) M61 Vulcan cannon, 725 rounds7 Hardpoints:  4 x AIM-9 Sidewinder, up to 4,000 lbs. bombs, rockets, drop tanks Operational History Entering service with 83rd Fighter Interceptor Squadron in 1958, the F-104A first became operational as part of the USAF Air Defense Command as an interceptor. In this role the type suffered teething problems as the squadrons aircraft were grounded after a few months due to engine issues. Based on these problems, the USAF reduced the size of its order from Lockheed. Lockheed F-104A Starfighter of the 83rd Fighter Interceptor Squadron at Taoyuan Air Base, Taiwan, on 15 September 1958, during the Quemoy Crisis. US Air Force While issues persisted, the F-104 became a trailblazer as the Starfighter set a series of performance records including world air speed and altitude. Later that year, a fighter-bomber variant, the F-104C, joined the USAF Tactical Air Command. Quickly falling out of favor with the USAF, many F-104s were transferred to the Air National Guard. With the beginning of the US involvement in the Vietnam War in 1965, some Starfighter squadrons began to see action in Southeast Asia. In use over Vietnam until 1967, the F-104 failed to score any kills and suffered a loss of 14 aircraft to all causes. Lacking the range and payload of more modern aircraft, the F-104 was quickly phased out of service with the last aircraft leaving USAF inventory in 1969. The type was retained by NASA which used F-104 for testing purposes until 1994. An Export Star Though the F-104 proved unpopular with the USAF, it was exported extensively to NATO and other US-allied nations. Flying with the Republic of China Air Force and Pakistan Air Force, the Starfighter scored kills in the 1967 Taiwan Strait Conflict and India-Pakistan Wars respectively. Other large buyers included the Germany, Italy, and Spain who bought the definitive F-104G variant beginning in the early 1960s. Featuring a reinforced airframe, longer range, and improved avionics, the F-104G was built under license by several companies including FIAT, Messerschmitt, and SABCA. In Germany, the F-104 got off to a bad start due to a large bribery scandal that was associated with its purchase. This reputation sank further when the aircraft began suffering from an unusually high accident rate. Though the Luftwaffe endeavored to correct problems with its F-104 fleet, over 100 pilots were lost in training accidents during the aircrafts use in Germany. As losses mounted, General Johannes Steinhoff grounded the F-104 in 1966 until solutions could be found. Despite these problems, export production of the F-104 continued until 1983. Utilizing various modernization programs, Italy continued to fly the Starfighter until finally retiring it in 2004.

Sunday, November 3, 2019

45 year old male diagnosed with metabolic syndrome Essay

45 year old male diagnosed with metabolic syndrome - Essay Example at take place in the body of patients over time is very important in giving very accurate symptomatic diagnosis that is focused on the giving very specific and efficient management and treatment plans. This paper is dedicated to outlining some of the major forms of pathophysiology changes that take place in the blood vessels of patients over time. This shall be done with specific emphasis on all known aspects of the pathophysiology of Type 2 DM. The rationale behind this approach is that different aspects of the pathophysiology of Type 2 DM come about as a result of changing pathological and physical processes that are take place in the blood vessels of patients over time. Once the right form of management model is given, it is possible to suppress some aspects of the pathophysiology from taking place. In the current case, the 45 year old patient who has been recently diagnosed with Type 2 DM has been noted to have a history of metabolic syndrome. Despite the fact that Type 2 DM is naturally associated with high blood sugar level, the patient is actually suspicion of the fact that his situation with high blood sugar level could be something that was there as a result of the metabolic syndrome. This makes it important to find the relationship between metabolic syndrome and diabetes and find a link between their pathophysiology. Beckman, Creager and Libby (2009) indicated that metabolic syndrome and diabetes indeed have very close relation in terms of both physical and pathological conditions that makes it important to put patients with metabolic syndrome on the lookout for diabetes. This is because patients with metabolic syndrome exhibit a disorder in their energy utilization and storage, which comes about as a result of a number of medical conditions. But because the conversion a nd usage of the energy within the body could trigger a saturated concentration of blood sugar, the chance of developing Type 2 DM has been pegged at four times higher for patients with

Friday, November 1, 2019

Alone as We Grieve Essay Example | Topics and Well Written Essays - 1250 words

Alone as We Grieve - Essay Example In any case, one thing is sure; body, mind, and spirit are the essential constituents of a living person. We know that our body gets destroyed after the death. However, we do not know what happens to the soul after death. There are plenty of people who believe that soul cannot be died even after the death of a person, as it is a form of energy, which drives our body. They substantiate their arguments with the help of scientific principles. Science accepts the existence of an energy, which drives our body. But, scientific principles say that energy can neither be created, nor be destroyed. If that is true science should explain what happens to the soul (energy) after death. In short, nobody can deny the existence of life after death. Didion’s experiences and feelings after the death of her husband can be analyzed under the above context. Didion wants to be alone—especially on the night of her husband’s death—but at other times she seems surrounded by people . In the following essay, I will examine the relationship between grief as we imagine it, and grief as it really is, in Joan Didion’s After Life†. â€Å"I remember a sense of shock. I wanted to say not yet but my mouth had gone dry. I could deal with â€Å"autopsy† but the notion of â€Å"obituary† had not occurred to me† (p11). These words clearly suggest the deep attachment Didion had with her husband. It should be noted that the autopsy is normally conducted on dead bodies, which are unknown to the doctor. At the same time, the word obituary we normally use when some of beloved ones passes away. In both the cases, one may feel grief, but the grief felt in the second case is deeper than the grief felt in the first case. â€Å"Grief is different. Grief has no distance. Grief comes in waves, paroxysms, sudden apprehensions that weaken the knees, blind the eyes, and obliterate the dailiness† (p10). It is difficult to define grief in simple ter ms. Pain, helplessness and physical humiliation are some of the characteristics of grief. While pain affects both body and mind, grief affects only the mind or soul. Grief comes as waves and sudden apprehensions whereas pain affects a person continuously. All humans in this world should have experienced some kind of pain during their lifetime. Therefore, anybody can define pain in their own ways. However, it is difficult for a person who never experiences actual grief to define grief exactly. In other words, what we think about grief is actually different from what we feel because of grief. For example, it is easy for a person to give soothing words to the person who experiences grief. He may even criticize the griever for not controlling his/her grief. This is because of the differences about the perceptions of grief and the feeling of grief. Grief, when it comes, is nothing we expect it to be. It is not what I felt when my parents died. what I felt in each instance was sadness, lo neliness, regret, for time gone by, for things unsaid, for my inability to share or even in any real way to acknowledge, at the end, the pain and helplessness and physical humiliation they each endured (p.10). Death of beloved ones always generates grief in the minds of a person. However, it is not necessary that the grief generated by the death of parents is same as the grief generated by the death of husband or children. Even though a person may have only one mother and father, that mother and father may have more than one child. So, grief generated

Wednesday, October 30, 2019

Report performance management (base pay & benefit) Essay

Report performance management (base pay & benefit) - Essay Example Performance management is a developing subject area. Not many current and up to date books are available. Journal articles are more helpful providing to the point and current research material. The material used is basically based on material printed in last five or six years. Material related to the Performance Management mostly depicts diverse direction of thinking by different practitioner and the theories stated by them. Findings: There is a big room for improvement, which is required for the company to improve its performance management process. It is also noticed from the previous research that the activities related to performance management process in the company were not synchronized with the organisational culture of the company. Limitation of the study: - There is a vast area related to the topic addressed, which needs to be researched and analyzed. The comparative study of performance management practices in different countries could also be undertaken. Practical implications: The study is a fair effort to help the individuals and the professionals attached to the field to understand the benefits attached to the right performance management process in the development of a company. Mullins (1998) defined motivation is a complex subject and is influenced by many variables. Individuals have a variety of changing, which they attempt to satisfy in a number of different ways. Motivation at work operates in two ways. First, people can motivate themselves by seeking, finding and doing work which leads them to expect that their goals will be achieved. Second, people might be motivated by management through such methods as pay, promotion and praise. These two ways can be described into two types of motivation (Armstrong, 1999): Intrinsic motivation- It can be described as the process of motivation by the work itself in so far as it satisfies people's needs or at least leads them to expect that their goals will be achieved. It is self-generated factors which influence people to behave in a particular way or to move in a particular direction. Intrinsic motivation refers to the intrinsic attractiveness of work itself (Child, 1994; Jackson & Bak, 1998; Tung, 1991). Extrinsic motivation- This includes rewards such as increased pay, praise or promotion. It is crude, easy and often effective. Money is individual basic need. As Duall (1999) said that when individuals are able to satisfy their perceived needs, they see themselves as being successful. In this view, the desire to achieve personal success is a natural phenomenon, and people are self-motivated to achieve, grow, and develop in positive ways (Greenberg, 1986a & b). Herzberg Motivator Hygiene Theory Herzberg (1966) proposes that all individuals have two sets of needs hygiene and motivator. Hygiene factor affect job dissatisfaction, these include such things as quality of supervision, pay, company policies, physical working conditions, interpersonal relations and job security. Job satisfaction appeared to be caused by motivator factors; these include promotional opportunities, opportunities for personal growth, recognition, a sense of achievement and responsibility. Most of the employees prefer to be recognized and appreciated through increment in pay

Sunday, October 27, 2019

Kappa Agonists in Management of Pain and Opioid Addiction

Kappa Agonists in Management of Pain and Opioid Addiction Joseph Nguyen Abstract Hypothesis: Opiates mediate pain via opioid receptors, which consist of several subtypes. One subtype, the kappa opioid receptors (KOR), has also been shown to prevent addictive behaviour. Potential novel therapeutic compounds acting on KOR include U50488, CR665, and CR845. It is hypothesized that selective kappa opioid receptor agonists are effective at controlling pain while managing opioid addiction. Methods: Studies for this review were obtained through the PubMed database using a keyword search strategy. Only articles in English published from December 2006 until December 2016 were considered. Results: Kappa agonists are able to decrease inflammatory, visceral, and surgical pain, but are unable to inhibit behaviour-depressing aspects of pain. Kappa agonists also decrease field potential and long-term potentiation in the basolateral amygdala. Additive anti-nociception with mu opioids has been observed as well as decreased fentanyl use, morphine tolerance development, and morphine withdrawal symptoms. Conclusions: Kappa agonists can be effective analgesics while also preventing abuse and addiction to mu opioids. Some evidence also suggests kappa agonist activity in the basolateral amygdala can inhibit affective components of pain. Abstract Word Count: 175 Keywords: kappa agonist, pain, analgesia, anti-nociception, tolerance, dependence, withdrawal, addiction Ultramini Abstract: This study reviewed current research on the analgesic and anti-addictive properties of selective kappa agonists for their use in pain management while preventing addiction. Introduction Opioids are one of the most powerful analgesics available with an increasing trend of prescription in the United States. Prescriptions per capita increased 7.3% from 2007-2012 with 259 million prescriptions in 2012, enough for one bottle of opioids per adult (Dowell et al., 2016). On the other hand, use of opioids presents risks including dependence, abuse, addiction, and overdose which lead to negative health, social and economically impacts. From 1999 to 2014, over 165,000 people have died from opioid overdose and in 2013; an estimated 1.9 million people abused or were dependent on prescribed opioids (Dowell, Haegerich Chou, 2016). However, pain treatment should not be ignored as there are clinical, psychological, and social consequences associated with chronic pain including limitations in complex activities, lost work productivity, reduced quality of life, and stigma, emphasizing the importance of appropriate and compassionate patient care (Dowell et al., 2016). The CDC has recently released a guideline, aimed at primary care settings, suggesting prescriptive protocols as well as methods to evaluate risk of patient substance abuse and addiction. However, the majority of evidence reviewed by the guideline had significant limitations. Although the CDC guideline still has value in preventing exacerbation of pre-existing risk of abuse, results and implementation remain to be seen. Efforts have been made to deter abuse through novel drug formulations, barriers, and pharmacokinetics. Nevertheless, nothing can prevent an addicted person from taking multiple doses at once. This may be a result of the inherent nature of the drugs to activate reward pathways in the brain along with its analgesic effects though mu receptors. Another opioid receptor, kappa-opioid receptor (KOR), has been shown to limit motivational properties of drug abuse (Lalanne, Ayranci, Keiffer Lutz, 2014). This has sparked interest in development of kappa agonists as novel analgesics with low abuse potential. Examples of known selective kappa agonists include U50488, CR665, and CR845 among many others including those continuing to be developed. However, questions still remain about analgesic efficacy and complications for patients already addicted to mu opioids transitioning to kappa agonists. This literature review explores the anti-nociceptive efficacy of kappa agonists and their ability to m anage opioid addicted patients. Balancing adequate pain control with risk of future abuse has been a difficult endeavour for physicians as well as patients. This topic was chosen to investigate the possibility of a potent pain medication without addictive properties as an alternative to traditional mu opioids. Surely, this would be a major instrument in the treatment of chronic pain. This study will be done under the hypothesis that kappa agonists are effective in management of pain and opioid addiction. Methods A search was performed for published literature on PubMed. Search terms were selected to assess analgesic properties and anti-addiction properties of kappa agonists on opiate use (Table 1). The search terms used included: pain, chronic pain, kappa opioid, kappa agonist, pain control, anti-nociception, withdrawal, dependence, addiction, and tolerance. This study looked at articles in English published between December 2006 and December 2016. Articles of all levels of evidence were considered and included review, preclinical, and clinical data. The initial search produced 574 results. These resources were then screened with the following exclusion criteria: articles not involving kappa agonists/receptors, articles on opioids without kappa receptor selectivity, articles on opioids with dual agonist activity, articles on kappa agonist interaction with drugs that were not analgesics. Abstract reviews of the remaining articles were performed to select for articles on analgesic efficacy or anti-addictive properties of selective kappa agonists. The resulting collection of evidence was organized into an evidence table (Appendix). Table 1-Keyword Search Strategy Population Intervention Comparison Outcome Pain OR Chronic Pain Kappa opioid OR Kappa agonist Analgesia OR Analgesic OR Pain control OR Antinociception OR Anti-nociception OR Withdrawal OR Dependence OR Addiction OR Tolerance Results A final total of 11 articles were included in this study, the majority being animal studies on mice or rats. One study involved rhesus monkeys. There was one study that involved a human clinical trial. Also, there was one review using human clinical trials focused only on peripherally selective kappa agonists. Table 2-Summary of Study Designs Reviewed Study Design # of Studies Animal Models 9 Clinical Trials 1 Review 1 Analgesic Efficacy An animal study by Auh and Ro (2012) induced inflammation in rat hindpaws with injections of complete Freunds adjuvant. After 3 days, when mechanical hyperalgesia was well developed, local injections of kappa agonist U50488 were given at different doses and mechanical threshold for hindpaw withdraw response was measured. The results showed dose-dependent increase in mechanical threshold by local injections of U50488 (Auh Ro, 2012). A time effect was also observed where increasing doses of U50488 prolonged the anti-hyperalgesia effect. The role of kappa opioids in inflammatory pain was also studied by Moon et al. (2016) in a research on the effects of peripheral kappa opioid receptors and arthritic pain. Arthritis was induced in rats using 1% ÃŽÂ »-carrageenan injected into the knee. After nociceptive behaviour was maximally expressed (reduced weight-bearing in ipsilateral joint), U50488 was injected into affected joints. A two-way repeated-measure ANOVA showed significant recovery of reduced weight-bearing in the affected limb in comparison to saline. In addition to inhibited nociceptive behaviour, U50488 was also found to reduce mechanosensitive afferent nerve fibre activity in the carrageenan-induced inflamed knee using nerve recording techniques. Aside from inflammatory pain relief by U50488, the peripheral kappa opioid CR665 was found to significantly increase pain threshold to esophageal distension in a study by Arendt-Nielsen et al. (2009). This randomized, double blinded, controlled study compared the effects of CR665 against oxycodone on skin, muscle, and visceral pain stimulation in healthy males. Although CR665 increased pain threshold to esophageal distension, oxycodone had the same effect with addition to increased pain threshold to cutaneous pinch pain, cuff pressure pain, and thermal stimulation. A number of other clinical trials, on peripheral kappa agonist CR845, were reviewed by Albert-Vartanian et al. (2016). A randomized, double-blinded, placebo-controlled study was conducted on elective hysterectomy patients for analgesic efficacy before and after the procedure, using a 10 cm visual analog scale for measurement of pain intensity. If pain persisted after 24 hours, rescue medication (IV morphine) was given. Significant differences were observed in comparison to patients who only received placebo. Less use of rescue medication as well as a 2-fold decrease in pain intensity was found in patients that received CR845 before and after the surgery. Albert-Vartanian et al. (2016) also discussed a phase 2, randomized, double-blinded, placebo-controlled clinical trial in patients electing bunionectomy surgery with fentanyl as rescue medication. Over a 48 hour period, pain was measured regularly using a visual analog scale. The study used a sum of pain intensity difference from baseline levels over 24 hours (SPID ­0-24) as a measurement for efficacy along with SPID0-36 and SPID0-48. In patients who completed the study, there was a statistically significant reduction in SPID0-24 and SPID0-48 in those treated with CR845 compared to placebo. However, there was no significant difference in the modified intent-to-treat group. In another phase 2 trial, patients with moderate to severe osteoarthritis pain (>4 out of an 11 point scale) were given an oral form of CR845 with acetaminophen as a rescue drug over 2 weeks (Albert-Vartanian, 2016). A dose-dependent reduction in average pain score of 25-34% was observed. Among patients receiving the highest dose of CR845, 50% had a reduction of †°Ã‚ ¥30% in their reported pain score at the end of the 2 weeks with an 80% reduction in requirement for acetaminophen. Analgesic Efficacy with Other Measures of Pain Aside from sensory components of pain, there are affective and behavioural components of pain as well. An electrophysiological experiment conducted by Huge, Rammes, Beyer, Zieglgansberger, Azad (2009) looked at the effects of kappa opioid receptors activation on mice basolateral amygdala, an area of the brain that is involved in pain processing and pain memory formation. The field potential amplitudes were measured at baseline and under induced long-term potentiation using high frequency stimulation and the effects of kappa agonist U50488H were studied.   The experiment found that U50488H decreased baseline levels of field potential amplitude as seen in Figure 1, while these effects were inhibited by kappa receptor antagonist norbinaltorphimine (nor-BNI). Figure 1. Effects of Kappa Agonist and Antagonist on Field Potential Amplitude of Mice Amygdala. Baseline (BL): 100 ±0.5%; U50488H: 86.3 ±2.4%, nor-BNI: 100 ±4.2%. Data points show average field potential (FP)  ± Standard Error. Reproduced from Huge et al., 2009, p. 125. Prior application of U50488H before high frequency stimulation was also found to inhibit induction of long term potentiation (Figure 2) in comparison to long term potentiation induction with no drug (Figure 3). Figure 2. Effect of Kappa Agonist Pre-treatment on High Frequency Stimulated Long Term Potentiation of Mice Amygdala. U50488H: 100 ±4.1%; High Frequency Stimulation (HFS): 102.6 ±7%. Data points show average field potential (FP)  ± Standard Error. Reproduced from Huge et al., 2009, p. 126. Figure 3. Long Term Potentiation Produced by High Frequency Stimulation. Baseline (BL): 100 ±2%, High Frequency Stimulation (HFS): 119 ±4%. Data points show average field potential (FP)  ± Standard Error. Reproduced from Huge et al., 2009, p. 126. Although pain-stimulated behaviours are often used as a measure of pain, such as a withdrawal or writhing response, complementary measures are behaviours that diminish in the presence of pain stimuli (Negus, OConnell, Morrissey, Cheng Rice, 2011, p. 506-507). An experiment by Negus et al. (2011) studied the effects of peripheral and central kappa agonists compared to ketoprofen on rats trained to evoke intracranial self-stimulation using a lever, a behaviour that is depressed by pain. Intraperitoneal lactic acid injection acted as a pain-inducing stimulus, with a stretch response being a pain-stimulated behaviour to contrast with the pain-depressed behaviour of intracranial self-stimulation. It was found that the central kappa agonist (salvinorin A), peripheral kappa agonists (ffir and ICI204448), and ketoprofen all inhibited lactic acid induced stretching. However, only ketoprofen inhibited lactic acid induced depression of intracranial self-stimulation. Salvinorin A had actually i ncreased depression of intracranial self-stimulation while ffir and ICI204448 had no appreciable effect. Similar results were found when Negus et al. used depression of nesting in mice as a measure of pain (2015). Kappa agonist U69593 failed to both inhibit and reverse depression of nesting induced by intraperitoneal lactic acid and intraplantar complete Freunds adjuvant (Figure 4A 4B). However, 1-way ANOVA analysis (pFigure 4A 4B). U69593 was shown to actually depress nesting when administered independently (Figure 4C) and this effect was not able to be reversed by neither ketoprofen nor morphine (Figure 4D). Figure 4. Effects of Ketoprofen, Morphine, and U69593 on Nesting under Different Conditions. Panel A: Nesting depressed by intraperitoneal administration of 0.32% lactic acid. Panel B: Nesting depressed by intraplantar administration of complete Freunds adjuvant. Panel C: Nesting under no treatment. Panel D: Nesting depressed by U69593. Nesting represented as the number of zones cleared of nesting material. V represents drug vehicle only. Darkened points represent significant difference from drug vehicle under given condition. Reproduced from Negus et al., 2015, p. 18.       Interactions with Mu Opioids There is evidence suggesting kappa agonists have anti-addictive effects (Lalanne et al., 2014). However, it is important to evaluate the effects of kappa opioids in concurrent use with mu opioids. A study on interactions of fentanyl and U69593 in rhesus monkeys showed a decrease in the rate of drug self-administration when the kappa agonist was added to fentanyl compared to fentanyl alone (Negus, Schrode Stevenson, 2008). This effect increased with greater proportions of U69593 in the mixture (Figure 5). Using a conditioned response for food as a measurement for activity, both fentanyl and U69593 alone depressed the behaviour while mixtures showed a less than additive effect. Furthermore, at the lowest proportion tested (0.22:1 U69593/fentanyl), U69593 reduced the behaviour depressing effects of fentanyl. Figure 5. Rate of Self-Administration of Fentanyl vs. Dose of Fentanyl, U69593, or Mixture. Reproduced from Negus et al., 2008. Negus et al. also demonstrated additive thermal anti-nociception, using tail withdrawal threshold from heated water, with the fentanyl/U69593 mixtures at all proportions tested (2008). More evidence of additive effects of kappa and mu opioids was shown by Sakakihara, Imamachi, Saito using a similar method in mice (2016). Intrathecal injection of kappa agonist TRK-820 combined with morphine resulted in a stronger anti-nociceptive effect compared to morphine alone. Compared to morphine alone, kappa agonists also have benefits regarding the development of tolerance. It is well known that repeated use of mu opioids quickly develops tolerance. The addition of a kappa agonist has been shown to inhibit the development of tolerance to morphine (Hamabe, Yamane, Harada Tokuyama, 2008). Mice treated daily with subcutaneous morphine for 5 days developed reduced analgesia from morphine from days 3 to 5. However, daily administration of kappa agonist U50488H 5 minutes after injection of morphine attenuated the onset of tolerance (Figure 6). Additionally, pre-treatment of kappa receptor antagonist nor-BNI inhibited the tolerance-blocking activity of U50488H. Figure 6. Effect of Kappa Agonist U50488H on Morphine Tolerance. Each point show means  ± standard error. AUC: Area under curve. #: P Although U50488H inhibited the development of tolerance it was unable to inhibit morphine withdrawal (Tao et al., 2008). However, Tao et al. demonstrated that another kappa agonist, LPK-26, may be able to. Chronic doses of morphine, kappa agonist (LPK-26 or U50488H), or both were administered to mice over 5 days and induction of withdrawal was achieved by subcutaneous injection of naloxone 2 hours after the final dose of morphine. Chronic treatment with LPK-26 did not produce a withdrawal response. However, chronic treatment with morphine produced a strong withdrawal response in the form of withdrawal jumping. Furthermore, chronic treatment with morphine along with pre-treatment with LPK-26 had a significant reduction in withdrawal response in a dose dependent manner (Figure 7A). Body weight was also measured before and after naloxone withdrawal induction (Figure 7B). Only LPK-26 showed significant reduction of morphine-induced weight loss. Figure 7. Effects of LPK-26 and U50488H on Withdrawal Jumping and Weight Loss. Data set shown as mean  ± standard error. Reproduced from Tao et al., 2008, p.310. Discussion Analgesic Efficacy of Kappa Opioids Side effects of selective kappa agonists mainly stem from its activity in the central nervous system. These side effects are the main hindrance for pharmacologic use of kappa opioids and include dizziness, dysphoria, confusion, sedation, hallucinations, diuresis, and even psychotic symptoms at high doses (Walsh, Strain, Abreu, Bigelow, 2001). Strategies to minimize these unwanted effects revolve around limiting the activity of kappa agonists to peripheral sites of action. Local injections have been shown to reduce inflammatory pain in animal models through reduced activity of afferent nerve fibres (Auh Ro, 2012; Moon et al., 2016). Although the analgesic results mentioned were limited to animal models, in humans, intravenous administration of peripherally selective formulation CR665 also shows evidence of analgesia for visceral and surgical pain (Arendt-Nielsen et al., 2009; Albert-Vartanian et al., 2016). Furthermore, oral formulations CR665 have been shown to reduce inflammatory osteoarthritic pain in humans (Albert-Vartanian et al., 2016). Continued pain treatment is required if kappa opioids are to be considered as an alternative to mu opioids and research shows viability of kappa opioids in different formulations and routes of administration for the treatment of pain in traditional measures. The components of pain include affective elements as well, which is especially important in chronic pain. Pain affect is comprised of the unpleasant emotions associated with pain as well the emotions towards future implications of having chronic pain. The latter is based on reflections of pain memory and is known as secondary pain affect. As a consequence, chronic pain states can lead to depression and anxiety, which lowers well-being and quality of life (Price, 2000). The amygdala is a crucial structure in the brain involved in emotional learning, pain processing, and constructing of pain memories (Huge et al., 2009). Kappa opioids are able to reduce the activity and inhibit long-term potentiation in the basolateral amygdala. As long-term potentiation is considered a cellular model for learning and memory formation, kappa opioids may be able to prevent or extinguish pain memory and treat affective components of pain. However, this experiment, at the moment, is limited to mice and fu rther study is required to assess whether the results can be translated to human.   Furthermore, these results may be due to structurally specific central actions on the amygdala as other studies show evidence of dysphoric effects from central kappa opioid receptor activation (Lalanne et al., 2014). Although kappa agonists have regularly been shown to provide analgesia in assays using pain-stimulated behaviours as measurements of pain, there is contrast when pain-depressed behaviours are observed instead. Pain-depressed behaviours are behaviours that are decreased due to pain. Some examples that have been tested in animal models are feeding, movement, and reinforced behaviours. In humans, it is analogous to mood or functionality. When pain-depressed behaviours are studied, not only do centrally active kappa agonists fail to relieve pain of this aspect, they may worsen it (Negus et al., 2012; Negus et al., 2015). It should be noted that peripherally active kappa agonists relieve pain in pain-stimulated assays without affecting pain in pain-depressed assays and may be safer than centrally active kappa agonists (Negus et al., 2011). In comparison to kappa opioids, conventional analgesics such as mu opioids and nonsteroidal anti-inflammatory drugs do relieve such components of pain in addition to pain-stimulated behaviours (Negus et al., 2011; Negus et al., 2015). Even so, kappa agonist still have value as they have been shown to reduce pain in human trials as discussed previously. The studies on pain-depressed behaviours have limitations to animal models and further studies are needed to understand how clinically relevant the effects may be for humans. Managing Addiction Some of the major problems of using mu opioids for pain control are the development of tolerance, dependence, and drug abuse, which may all contribute to addiction. Although there are many other drugs that also relieve pain, the difficulty lies in managing addiction at the same time. Kappa agonists, aside from having low abuse potential, have been shown to decrease self-administration of fentanyl in animal models (Negus et al., 2008). These results are promising evidence for kappa agonists being agents to prevent opioid abuse. Also, kappa agonists have additive analgesic effects with mu opioids (Negus et al., 2008; Sakakihara et al., 2016). This possibly reduces the amount of mu opioid required for effective pain management while also reducing addiction and abuse liability due to less use. Increased usage of mu opioids may be due to the development of tolerance, requiring increased dosage to maintain analgesia. The high addictive potential of mu opioids makes this a concerning issue. However, addition of kappa agonists during administration of mu opioids may be able to significantly inhibit the development of tolerance (Hamabe et al., 2008). It may be possible to prevent the development of physical dependence and addiction to mu opioids by adding kappa agonists to drug regimens of chronic pain patients. As for those who are already affected by physical dependence on mu opioids, there is evidence that kappa opioids can inhibit withdrawal symptoms and reduce dependence (Tao et al., 2008). However, some kappa agonists, such as U50488H, do not have any significant effect. It has been suggested that the inconsistency may be due to varying affinities for different subtypes of kappa opioid receptors. Nonetheless, this study demonstrates potential for kappa agonists in managing opioid addiction through modulating dependence and withdrawal. Future studies may provide better understanding on subtype functions and improve designs for desired effects while minimize side effects. Also, as the studies regarding kappa agonist interaction with mu opioids are mainly done on animal models, further investigation is required to see whether results can be extended to humans. One important point to distinguish is non-selective versus peripherally selective kappa agonists. As mentioned previously, activation of kappa receptors in the central nervous system can lead to many side effects. Peripherally selective kappa agonists still produces analgesia, but it is uncertain whether the effects of the kappa agonists on abuse, tolerance, and dependence are due to central or peripheral activity. If these effects are due to central activity, the benefits of kappa agonists for addiction management will be limited by their undesired side effects. Still, in a study involving a peripherally selective kappa agonist and its effects on nicotine, there is some evidence suggesting that activation of peripheral kappa receptors do inhibit symptoms of withdrawal and dependence by inhibiting activity of central kappa receptors. Conclusion In conclusion, this study found that selective kappa agonists provide analgesia to inflammatory, visceral, and surgical pain. In contrast, they were not effective inhibitors of behaviour-depressing effects of pain. Specific activities of kappa receptors in the basolateral amygdala, however, may inhibit affective components of pain.   In managing addiction, kappa agonists may able to prevent mu opioid abuse, prevent the development of tolerance, inhibit the symptoms of withdrawal, and reduce physical dependence. The additive effect with mu opioids and the inhibition of tolerance development can reduce the required amount of mu opioids for effective analgesia, thus reducing abuse and addiction likelihood. Overall, selective kappa agonists are a good prospect for managing pain while combating opioid abuse and addiction. Appendix Evidence Table First Author Date of Publication Study Design Level of Evidence Study Population Therapy or Exposure Outcome/Results Albert-Vartanian 2016 Review 1 Human CR845 CR845 reduced pain with less abuse potential Arendt-Nielsen 2009 Clinical trial 1 Healthy males CR665, Oxycodone CR665 is effective on visceral pain Auh 2012 Animal model 0 Rats U-50488 Local kappa agonist attenuated inflammatory mechanical hyperalgesia Hamabe 2008 Animal model 0 Mice Morphine, U-50488H Analgesic tolerance to morphine is prevented by U-50488H through suppression of PKC Huge 2009 Animal model 0 Mice U-50488H Activation of kappa receptors decrease synaptic transmission and long term potentiation in the amygdala Moon 2016 Animal model 0 Rats U-50488, Nor-BNI U-50488 inhibits nociception in arthritic knee joints of rats Negus 2008 Animal Model 0 Rhesus Monkey Fentanyl, U69593 Addition of kappa agonist to fentanyl demonstrated additive anti-nociception and decreased drug self administration Negus 2011 Animal Model 0 Rats Ffir, ICI204448, Salvinorin A Kappa agonists do not inhibit pain-depressed behaviours Negus 2015 Animal model 0 Mice Morphine, Ketoprofen, U69593 Morphine/Ketoprofen inhibited pain-depressed behaviours whereas U69593 failed to do so Sakakihara 2016 Animal Model 0 Mice Morphine, TRK-820, Nor-BNI Addition of kappa agonist to morphine may have additive anti-nociceptive effects Tao 2008 Animal Model 0 Mice Morphine, LPK-26, U50488H LPK-26 is a potent analgesic with low dependence and inhibits morphine withdrawal